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Thus, Ca2+transport from the lumen of the T tubule into the sarcoplasmdoesnotoccurand isnotessentialtotrigger thecontractioncycle.Instead, activation of these sensors opens gated Ca2+-releasechannels (ryanodine receptors) in adjacent terminal sacsofthe sarcoplasmic reticulum, causing the rapid release ofCa2+into the sarcoplasm. Antiag-ing effects from improved autophagy are robust (Petro-vski and Das, 2010) and include lifespan extension.

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Surgical treatment of sternoclavicular joint infections incirrhotic patients. This is a particular concern considering high-dose IL-2 therapy isused to augment the effectiveness of the transferred T cells.

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